Formulation and Evaluation of Oral Mucoadhesive Microspheres of Ofloxacin for Peptic Ulcer Use

A peptic ulcer is a disease that affects the stomach lining caused by Helicobacter pylori. The present research aimed to formulate and evaluate mucoadhesive microsphere of ofloxacin for effective safe treatment ulcers. microspheres were developed using natural polymers like Guar gum, Sodium alginate, Chitosan emulsification cross-linking method. total 8 batch formulations prepared 23 full factorial designs. evaluated various parameters such as % yield, entrapment efficiency, drug release study, in vitro wash-off test, optimization was done design expert which further subjected statistical analysis kinetic mechanism, compatibility studies performed FTIR DSC. Using maximum possible formulation, optimized formulation found be F5 terms better longer time with properties on use guar sodium chitosan ratio 1:1:2. Second-order polynomial equations derived absorbing responses after application ANOVA, omitting non-significant (p ≥ 0.05) coefficients. %CDR 56.10 an extended period h, EE exhibited 86.25±1.16. sustained activity might due adhesion polymer gastric mucosa more periods 71 h. it also favoured suitable particle size formulation. result indicated can manner helps management ulcer. HIGHLIGHTS Ofloxacin loaded designs Drug from h effectively deliver part GRAPHICAL ABSTRACT